Author’s response to reviews Title: Renoprotective RAAS inhibition does not affect the association between worse renal function and higher plasma aldosterone levels. Authors:
نویسندگان
چکیده
Title: Renoprotective RAAS inhibition does not affect the association between worse renal function and higher plasma aldosterone levels. Authors: Christina Gant ([email protected]) Gozewijn Laverman ([email protected]) Liffert Vogt ([email protected]) Maartje Slagman ([email protected]) Hiddo Heerspink ([email protected]) Femke Waanders ([email protected]) Marc Hemmelder ([email protected]) Gerjan Navis ([email protected]) Version: 3 Date: 23 Oct 2017 Author’s response to reviews: Department of Internal Medicine/Nephrology ZGT Hospital Zilvermeeuw 1 7609 PP, Almelo The Netherlands
منابع مشابه
Renoprotective RAAS inhibition does not affect the association between worse renal function and higher plasma aldosterone levels
BACKGROUND Aldosterone is elevated in chronic kidney disease (CKD) and may be involved in hypertension. Surprisingly, the determinants of the plasma aldosterone concentration (PAC) and its role in hypertension are not well studied in CKD. Therefore, we studied the determinants of aldosterone and its association with blood pressure in CKD patients. We also studied this during renin-angiotensin-a...
متن کاملBetween-patient differences in the renal response to renin-angiotensin system intervention: clue to optimising renoprotective therapy?
Renin-angiotensin-aldosterone system (RAAS) blockade with angiotensin-converting enzyme inhibitors (ACE-I) or angiotensin II (Ang II), AT(1)-receptor blockers (ARB) is the cornerstone of renoprotective therapy. Still, the number of patients with end-stage renal disease is increasing worldwide, prompting the search for improved renoprotective strategies. In spite of proven efficacy at group leve...
متن کاملThe Renin-Aldosterone axis in kidney transplant recipients and its association with allograft function and structure
The level of the renin-angiotensin-aldosterone system (RAAS) activity in kidney transplant recipients has not been extensively studied or serially profiled. To describe this axis and to determine its association with glomerular filtration rate (GFR) change, interstitial expansion, and end-stage renal disease (ESRD), we measured plasma renin activity (PRA) and plasma aldosterone levels annually ...
متن کاملRenoprotection: a matter of blood pressure reduction or agent-characteristics?
Data from recent clinical trials show that lowering of BP reduces the rate of renal function loss in chronic renal disease. There is evidence supporting the assertion that BP lowering obtained by intervention in the renin-angiotensin-aldosterone system (RAAS) has an additive renoprotective effect in both diabetic and nondiabetic renal diseases. However, to dissociate BP-dependent and non-BP-dep...
متن کاملTransdermal contraception and the renin-angiotensin-aldosterone system in premenopausal women.
The oral contraceptive pill (OCP) activates the renin-angiotensin-aldosterone system (RAAS) through first-pass hepatic metabolism. Although usually benign, RAAS activation may have detrimental effects on renal and hemodynamic function in some women. Since combined hormonal contraception with the transdermal patch (EVRA) does not undergo first-pass hepatic metabolism, we hypothesized that the RA...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017